Durable reprogramming of neutralizing antibody responses following Omicron breakthrough infection
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) breakthrough infection of
vaccinated individuals is increasingly common with the circulation of highly immune evasive
and transmissible Omicron variants. Here, we report the dynamics and durability of recalled
spike-specific humoral immunity following Omicron BA. 1 or BA. 2 breakthrough infection,
with longitudinal sampling up to 8 months after infection. Both BA. 1 and BA. 2 infections
robustly boosted neutralization activity against the infecting strain while expanding breadth …
vaccinated individuals is increasingly common with the circulation of highly immune evasive
and transmissible Omicron variants. Here, we report the dynamics and durability of recalled
spike-specific humoral immunity following Omicron BA. 1 or BA. 2 breakthrough infection,
with longitudinal sampling up to 8 months after infection. Both BA. 1 and BA. 2 infections
robustly boosted neutralization activity against the infecting strain while expanding breadth …
